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Inositol trisphosphate (IP3)/diacylglycerol (DAG) signaling pathway GPER activates the phosphatidylinositol-4,5-bisphosphate (PIP2) signaling pathway through Gq [38, 39]

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The live probiotics are generally more effective than heat-killed preparations for mechanisms requiring metabolic activity (e.g., SCFA production, immune modulation), although toxin binding may persist after heat inactivation (98)

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