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doi: 10.3389/fpls.2018.00751 Received 15 February 2018 Accepted 16 May 2018 Published 07 June 2018 Volume 9 - 2018 Edited by Kendal Hirschi, Baylor College of Medicine, United States Reviewed by Toshiro Shigaki, The University of Tokyo, Japan

2.4.5 Hematological examination Approximately 16 mL of venous blood was collected from each participant during each visit

Use of tesamorelin outside of its approved indicationincluding for general weight loss, anti-aging, or wellness purposeshas not been established through FDA approval and remains investigational

Several factors may contribute to these discordant results, and the lack of clear and robust findings, which are listed below: 1) SIM has a complex and inexplicit pathogenesis