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Vaccinia-related kinase 2 blunts sorafenibs efficacy against hepatocellular carcinoma by disturbing the apoptosis-autophagy balance

L., & Xu, L

& Kagan, J

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Since the liver has an abundant vascular structure and peripheral lymph distribution, ICC is prone to intrahepatic and extrahepatic metastases, and distant metastasis occurs in 70% of clinical autopsies ( Radical surgical resection is currently the only possible curative method for ICC, with a 5-year survival rate of about 30% and a 5-year recurrence rate of 60%70% ( Conclusions ICC with rectal metastasis is a rare mode of distant metastasis that may pose a diagnostic challenge