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GLP-1Rs are widely expressed in areas of the mesolimbic reward pathway that receive direct projections from the nucleus tractus solitarius (NTS) (Alhadeff et al., 2012)

Health explains, "Obesity is a chronic, multifactorial disease influenced by hormonal regulation, central appetite pathways, and the brains reward system

These findings illustrate that absolute percentages vary widely by CpG site, tissue and methodology, and that direct data from autoimmune cohorts remain scarce (81-83)