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Another randomized study in 44 breast cancer patients receiving paclitaxel reported lower levels of motor and sensory peripheral neuropathy in patients who wore frozen gloves/socks from 15 minutes before chemotherapy until 15 minutes after chemotherapy (Shigematsu 2020)

10.1038/nature13165 18

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The proposed physiological function of GHK in plasma involves copper delivery exchanging copper with albumin (the major plasma copper carrier) and with cellular copper-binding proteins, contributing to the regulated movement of copper through plasma and into tissues