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In the human body, the quercetin metabolites excreted through urine take up 20%60% of total quercetin intake and they are mainly composed of monoglucuronide sulfates, methylated quercetin monoglucuronides, and quercetin diglucuronide ( Previous experiments and studies have revealed the pharmacodynamics of quercetin, it is found that due to its chemical structure, it has low water solubility, oral absorption rate, rapid elimination, and low bioavailability ( 3 Quercetin in traditional herbal medicines Except for various food and supplements, quercetin is widely abundant in flowers, leaves and fruits of plants
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It is suggested that the genetic variation of E2 gene itself or very close to the gene is one of the genetic risk factors of PD, implying an important role of KGDHC in PD [79]
Following the first four weeks, dosages may be raised once weekly by 2.5 mg increments, if tolerated, up to a maximum of 15 mg
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