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While mild, occasional heartburn may be manageable with lifestyle modifications and over-the-counter remedies, certain symptoms warrant prompt medical evaluation

In particular, signals from the gut can activate specialized neurons of the arcuate nucleus (ARC) that regulate energy and glucose homeostasis, including agouti-related peptide/neuropeptide Y orexigenic neurons and pro-opiomelanocortin/cocaine and amphetamine-regulated transcript anorexigenic neurons 22,33,34,35

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The other modality is monopolar RF, which provides deep-tissue heating and is best for the neck and body areas where deeper penetration is required