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Infection and Immunometabolism in the Central Nervous System: A Possible Mechanistic Link between Metabolic Imbalance and Dementia
DOI: 10.1016/0306-3623(95)02149-3
doi: 10.1016/j.molmet.2020.100991
In conditions of nutrient depletion, ULK1 is activated, which leads to phosphorylation of the components of the Class III PI3K vacuolar protein sorting 34 (VPS34) protein complex, resulting in the formation of autophagosome and promoting the autophagy flux [255]
NNC0090-2746 (RG7697) is a compound that has been tested in multiple preclinical and clinical studies as a dual GIPR/GLP-1R agonist [58,59,60]
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