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ABCG2, while important in blood-brain barrier transport of UA and other molecules, is not reportedly found on human neurons 47

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Recognizing these uncertainties, analysts estimates on the future penetration of GLP-1RA and the shape and timing of this growth vary significantly and are highly speculative at this stage

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In clinical trials of Wegovy (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise