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Recent advancements in research have greatly enhanced our comprehension of BBB dysfunction and furnished us with strategies aiming at restoring the structural and functional BBB in neurodegenerative diseases

Together, these findings suggest that KYN-driven oxidative stress is not merely an epiphenomenon of depression but a mechanistic contributor to mitochondrial dysfunction, neuroprogression, and systemic comorbidity, highlighting redox modulation as a critical interface between inflammation, KP activity, and depressive pathology

Finally, while GHK-Cu is promising, its most effective when used as part of a comprehensive care plan tailored to the dogs unique health needs

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