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The study demonstrated that in spontaneously hypertensive rats, liraglutide reduced circulating Ang II levels, upregulated cardiac angiotensin II type 2 receptor (AT2R) and angiotensin-converting enzyme-2 (ACE2) expression, and attenuated myocardial hypertrophy [145]
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For longitudinal measures approach (baseline, middle of treatment, end of treatment, and follow-up period), a mixed linear regression with a random effect on the individual to estimate the mean change score in each category of patients were used
Larger reductions usually happen after dose increases
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