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DOI: 10.5599/admet.1.4.24 Since direct prediction of implicit solubility yielded inferior results to aqueous-solubility prediction ( vide supra ), pHsolubility curves were generated by (1) predicting aqueous solubility at a neutral pH , (2) converting aqueous solubility to intrinsic solubility by multiplying by the Starling-computed at pH , and (3) multiplying this by to convert back to aqueous solubility at different pH values