The "central plan" of GLP-1 RA is not limited to individual cells, but also achieves the reconstruction of whole-body energy metabolism through the neuroendocrine immune network: GLP-1 receptors are highly expressed in areas such as the hypothalamus and solitary tract nucleus of the brain, and their activation can inhibit the activity of appetite centers (such as NPY/AgRP neurons), while enhancing the transmission of satiety signals (such as POMC neurons)
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Key points: Wegovy can help overcome the weight loss challenges caused by hypothyroidism Weight loss may improve thyroid function and related health issues It can help break through weight loss plateaus when diet and exercise arent enough Individual results may vary, as hypothyroidism affects everyone differently Thyroid monitoring and management If you have hypothyroidism and start taking Wegovy, proper monitoring is essential for several reasons: How Wegovy affects thyroid hormones GLP-1 medications like Wegovy can slightly lower TSH levels through effects on your brains hormone control centre
Thein et al., 2020)
This involves activation of parasympathetic vagal outflow, and release from the gut 14 of GLP-1 15 , which, via the systemic circulation, reaches the heart and conveys cardioprotection