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At the lower doses used for diabetes, they have somewhat lower rates of diarrhea (9-12% for Ozempic, 12-21% for Mounjaro) compared to their weight management counterparts

M., Patel, R., & George, R

Researchers have identified other mitochondrial-derived peptides, such as Humanin and SHLPs, or small humanin-like peptides, but MOTS-C exhibits unique effects on energy sensing and gene regulation in response to metabolic stress

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Best Practice Tip: Request a renal function test at the same time as the serum urate (and CRP) to allow for prompt urate-lowering treatment initiation, should a diagnosis of gout be confirmed