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One of the key challenges was that the receptor has 463 amino acids

Based on these findings the authors concluded 'that central GLP-1 is a new physiological mediator of satiety' (Turton, O'Shea, Gunn)

Last reviewed: June 21, 2026 Last updated: June 21, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

In that article, he wrote that delayed gastric emptying (the digestive system holding food in the stomach for longer) is the likely main way that GLP-1s like Ozempic reduce overeating

GLP-1RA + Tesaglitazar)