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This results in decreased expression of the articulin CD2AP and the podocyte cytoskeleton protein synaptopodin, while increased expression of the transcription factor snail and nerphrin, a marker protein of podocyte injury, ultimately leads to podocyte actin skeleton remodeling and cell migration[94]

Science Translational Medicine , 12 (572)

People with a specific variant of the MTHFR (methylenetetrahydrofolate reductase) gene have an impaired ability to break down and use folate

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AyalaAMunozMFArguellesS.Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal