Experts are still learning why GLP-1s can cause diarrhea, but possible reasons include changes in how food moves through the gut or how the stomach and intestines communicate with each other
Patients with a history of malignancy, organ transplantation, or pre-existing dermatologic conditions of interestincluding atopic dermatitis, psoriasis, vitiligo, pemphigus, bullous pemphigoid, dermatomyositis, alopecia areata, lichen planus, cutaneous lupus erythematosus, hidradenitis suppurativa, systemic sclerosis, pyoderma gangrenosum, and morpheawere excluded at baseline
These agents act by inhibiting the PDE5 enzyme, thereby increasing cyclic guanosine monophosphate (cGMP) levels
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