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KLOW initiates intracellular signaling cascades particularly AMPK phosphorylation and klotho receptor-mediated pathways that remain active long after the peptide itself has been cleared from circulation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Dawed A.Y., Mari A., Brown A., McDonald T.J., Li L., Wang S., Hong M.G., Sharma S., Robertson N.R., Mahajan A., et al