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Carews experience not just minor nausea or pain, but a side effect with long lasting effects didnt fit the narrative

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The hormone's effects are relatively short-lived in the body, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), with a half-life of approximately 12 minutes

Clin Pharmacol Ther 88:801808 Napolitano A, Miller S, Nicholls AW et al (2014) Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus

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