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FIGURE 4-11 Plasma concentration versus time graph for long-acting oxytetracycline in horses, demonstrating flip-flop kinetics
One study found that doses of benzoic acid greater than 0.2g/kg daily or single doses exceeding 0.45g/kg resulted in hyperaethesia, apprehension, and depression 48 to 72 hours post uptake eventually resulting in death in some cats
Genomics 113 (3), 889899
Heres a general timeline of what patients might expect: Most patients see the most dramatic changes between months 3 and 6, with benefits continuing to build over time
The 2025 Brunel study helps, but broader independent replication across multiple institutions is needed
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