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This does not always mean GLP-1 therapy is impossible

Discussion In individuals with type 2 diabetes in whom diabetes was inadequately managed by GLP-1 RA therapy with or without additional oral glucose-lowering medications, once-weekly IcoSema demonstrated statistical superiority to semaglutide 1.0 mg with respect to HbA 1c reduction from baseline to week 52

Semaglutide is highly effective for obesity management, achieving mean weight losses of 1517% in clinical trials

Clinical trials of Foundayo (orforglipron) reported average A1C reductions ranging from about 1.2% to 1.7% depending on the dose, with many participants reaching target A1C levels below 7%

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