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Future direction: Multi target combination and cell therapy To overcome current limitations, the "central plan" intervention for GLP-1RA is moving towards the following directions: Multi target agonist development GLP-1/GIP/GCGR triple target agonists (such as Retatrutide) have entered phase III clinical trials, and their weight loss effect is expected to reach 22% -24%

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Similarly, supplementation with -tocopherol at a dosage of 400 IU/day resulted in a significant increase in the GSH/GSSG ratio in these subjects (Nor Azman et al