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People suffering from gastrointestinal problems including irritation from acid reflux or ulcer must use this supplement carefully as it may worsen their conditions

However, there is uncertainty about long-term benefit in terms of sustained weight loss and CV benefit, as well as the impact of potential tolerability concerns

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For example, while the maximum daily dose of acetaminophen was previously set at 4 g/day, the FDA Advisory Committee suggests decreasing it in an effort to reduce overdoses

Appetite suppression tends to take time to develop in this phase