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Substitution of valine with norleucine in the first position enhanced activity [85]

The analysis was done after the fact rather than as a primary endpoint, and the clocks were measured in blood, so they track systemic aging rather than the brain in particular

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106 found that patients with acute intrahepatic cholestasis had subnormal serum GGT activity despite high bilirubin levels, suggesting that factors inhibited the release of the enzyme into the blood stream from the liver

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