summit trial tirzepatide 408. Journal Club: The with Dr. Milton Packer JACC - #ACC25: A recent

Gastrointestinal Side Effects are the predominant category of adverse reactions: Nausea affects approximately 12-24% of diabetes patients and up to 30% of weight management patients, typically most severe during the first few weeks of treatment or following dose increases Diarrhea occurs in 13-17% of diabetes patients and up to 24% of weight management patients Vomiting is reported by 6-10% of diabetes patients and up to 12% of weight management patients, particularly at higher doses Constipation affects 6-11% of diabetes patients and up to 17% of weight management patients Dyspepsia and abdominal pain occur in 6-9% of patients Decreased appetite is common and contributes to the medication's weight loss effects Gastroesophageal reflux disease (GERD) occurs in some patients, particularly at higher doses These gastrointestinal symptoms typically diminish over time as the body adapts to the medication

If youre experiencing hair loss while on GLP-1s, consult your dermatologist for a specific diagnosis and a tailored approach to restore healthy hair growth

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Clinical data shows that roughly 70% of patients report manageable or minimal side effects by the end of week four

The screening takes under 10 minutes for most people