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Further investigation on signal transduction pathways among the three major pancreatic endocrine cell types demonstrated that the probability of interaction between key regulators of glucagon secretion, such as ligand-receptor pairs Sst-Sstr2 , Sst-Sstr3 , Ins1-Insr , and Ins2-Insr , were significantly reduced in GCGR-KO cells (Fig

The potential of neurotrophic therapy for PD and other neurodegenerative diseases has thus far been consistently thwarted by drug delivery limitations

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In coronary heart disease, accumulation of atherosclerotic plaque in the coronary arteries may prevent heart regions from getting adequate circulation, ultimately resulting in cardiac damage and impaired pumping ability