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& Dolores Dor Eccles Professor of Ophthalmology & Neuroscience, Wilmer Eye Institute, The Johns Hopkins School of Medicine involving oxidative stress in the retina provided impetus for exploring small molecule antioxidant therapies

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How it works: Mimics LH, directly stimulating Leydig cells in testes to produce testosterone

Low dose of salicylate (75, 150, and 325 mg per day) reduces urinary urate excretion and contributes to gouty risk (Zhang et al., 2014)

Since igf-1r null animals and igf-1/igf-1r double knockouts have similar growth and skeletal defects, it is proposed that the IGF-1R mediates all activities induced by this growth factor ( IGF-1 FUNCTION IN OSTEOGENIC CELLS Because chondrocytes, osteoblasts, osteoclasts, and many other cells in the bone express IGF-1R and IGF-1, global igf-1 and igf-1r knockouts are unable to exclude the effect of systemic perturbations of IGF-1 signaling on the skeleton