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Weight loss was accompanied by improvements in cardiometabolic parameters, including a decrease in systolic blood pressure (-9.9 mmHg) and waist circumference (-17.5 cm) (placebo-adjusted: 6.7 mmHg and 13.5 cm, respectively)

Notably, these studies found that simple endothelial cell cultures did not show the same angiogenic response, suggesting that BPC-157 may act as a context-dependent regulator of vascular signaling rather than a direct angiogenic stimulus

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doi: 10.1038/s41586-019-1705-2 191 KoppulaPLeiGZhangYYanYMaoCKondiparthiLet al

Bacteria changes may be linked to geographic location where the study was carried