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Hypoxia then stabilizes HIF-1 and upregulates REST, which suppresses GCLM/GPX4 expression and enhances ACSL4-dependent lipid peroxidationdirectly amplifying ferroptosiswhile also promoting the release of hypoxic extracellular vesicles (EVs) that propagate tubular ferroptosis in a paracrine manner

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Functional role of sperm surface glutathione (GSH) S-transferases and extracellular glutathione (GSH) in the haploid spermatozoa under oxidative stress

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