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The process begins with the extracellular breakdown of GSH into its constituent amino acidsglutamate and cysteineby hepatic -glutamyl transferase (GGT), an enzyme present only on the external surfaces of cell types, such as those of the hepatobiliary tree and heart [87,88]

6.1 Metabolic Context for GSH/GSSG Interpretation Metabolic context can be built by profiling cysteine/cystine, glutamate, glycine, and -glutamylcysteine

Free Radic Biol Med 2004;36:145-51

doi: 10.3390/diseases9010017 150 KryukovE