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Another issue is incomplete knowledge about the off-target actions of HDAC inhibitors

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Citation55 While these pathways prevent damaged cells from proliferating, they also promote inflammation and tissue dysfunction if senescent cells persist

Feingold KR, Grunfeld C

Although prolonged treatment with oral N-acetylcysteine (NAC) prevents acute exacerbations of chronic bronchitis, it remains controversial for the treatment of COPD (91, 103105)