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In pooled analyses of the STEP-HFpEF (Semaglutide Treatment Effect in People with obesity and HFpEF) and STEP-HFpEF-DM trials, GLP-1 RA had consistent beneficial effects on HF-related symptoms, exercise function, and inflammatory markers in patients receiving diuretics with obesity-related HFpEF [82]

glycoursodeoxycholic acid 3-sulfate and N-methylnicotinamide were modulated by all treatment groups with the same trend of modulation

37 The strength of the WD community internationally is underlined by the success of international symposia which have been held over the last several decades - the International Conference held in Leipzig in 2001 has already been mentioned

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Lifestyle and monitoring: Maintain regular follow-up appointments with the prescribing team or trial investigators to report any new or worsening symptoms