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Here, we used transient overexpression of NDI1 (ref

This early detection of the autoimmune process will help a person prevent a myriad of unpleasant symptoms, as well as the progression of the destruction of the thyroid gland, if the root cause of the condition can be identified

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The enzyme is activated allosterically by Sadenosylmethionine (SAM) and also by a cleavage at its carboxyl terminal at R413 to generate a 45 kDa monomer, which is not only twice as active as the full length form but also refractory to SAMmediated activation (Kery et al ., 1998