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Cancer 113: 29812994

Hydrogen Peroxide Sensing and Signaling

RNA was quantified using a NanoDrop ND-1000 Spectrophotometer (NanoDrop)

Compound 3 (VCT220) showed improved oral PK versus PF-06882961 (danuglipron), with ~21-fold higher Cmax and ~5.8-fold higher AUC in rats at 10 mg/kg, and 51% oral bioavailability in monkeys versus 8%