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More importantly, the synthesis of SAM, which requires the folate cycle, is crucial in neuropsychiatry for its role as a therapeutic agent in the treatment of depression, and as an antidepressant in Parkinsons disease (, , )

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561 fludrocortisone, a mineralocorticoid that promotes sodium and water retention to expand plasma volume, though it must be used cautiously due to the risk of supine hypertension and hypokalemia