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Glucagon-like peptide-1 receptor agonists: a narrative review of clinical Pharmacology and implications for peri-operative practice

When oxidative stress occurs, it damages neurons, disrupts signaling, and contributes to the progression of neurodegenerative disorders such as: Alzheimers disease Parkinsons disease Multiple sclerosis (MS) Amyotrophic lateral sclerosis (ALS) Over time, excessive oxidative damage impairs mitochondrial function the energy center of brain cells and accelerates neuronal decline

The albumin-binding chemistry was elegant and was validated at the bench: the identifying study showed that the maleimide-modified GHRH(1-29) conjugate activated the receptor and persisted in plasma for days in animals