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Large-scale phosphoproteomic studies have identified over 43,000 phosphorylation sites in Arabidopsis , revealing a highly complex and dynamically regulated network (Mergner et al

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[DOI] [PubMed] [Google Scholar] de Keizer PL, Burgering BM, Dansen TB

Finally, the pleiotropy-original sin hypothesis postulates that cell death is an immanent and inevitable process associated with the formation of metabolic by-products in cells like reactive oxygen species (ROS) and cell death machinery components-encoding genes were not initially related to cell death processes and performed pro-survival functions