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used in long-term human clinical trials Intravenous injection Used primarily for pharmacokinetic characterization and acute dosing studies in humans Intraperitoneal injection Standard route for chronic rodent studies

Citations [1] Mikus D, Sikiric P, Seiwerth S, Petricevic A, Aralica G, Druzijancic N, Rucman R, Petek M, Pigac B, Perovic D, Kolombo M, Kokic N, Mikus S, Duplancic B, Fattorini I, Turkovic B, Rotkvic I, Mise S, Prkacin I, Konjevoda P, Stambuk N, Anic T

1,2 Fluoxetine (SSRI) dosages of 10 mg to 80 mg daily have produced reductions in pain, depression, fatigue, and overall symptoms

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Sin embargo, en varios momentos a lo largo del da, los cientficos de la FDA sealaron que, simplemente, no haba datos que pudieran evaluar en el caso de ciertos pptidos