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Results GSH synthesis is required for the survival of adult animals To better understand the importance of GSH in adult mammals, we developed an inducible, whole-body Gclc KO mouse by breeding the Gclc f/f mouse strain 30 with the Rosa26-CreERT2 mouse strain 31

Actually, the unpublished data of our team indicates that acidosis can induce neural stem cell damage through excessive activated acid-sensing ion channels (ASICS), which are abundantly located on the dendritic spine of CSF-cNs

To more precisely examine the extent to which mitochondrial GSH depletion impacts erythropoiesis, we additionally generated a mouse model in which mitochondrial GSH import is disrupted specifically in the erythroid lineage (conditional SLC25a39-KO mice, ErGFP-cre

Following TBI, mice were monitored closely each day for signs of infection, bleeding, and general distress until the main study concluded on day 18

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