Emerging therapies, such as delgocitinib, a topical pan-JAK inhibitor, offer a promising solution by targeting multiple immune pathways involved in CHE pathogenesis
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Under some pathophysiological circumstances, endothelium-derived vasoconstricting factors, such as ET-1, AT-II, urotensin II, superoxide anions, vasoconstrictor prostaglandins and thromboxane A 2 , can be released and contribute to the paradoxical vasoconstrictor effects
Otherwise skip and resume next week
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