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Loui A, Raab A, Maier RF, Bratter P, Obladen M

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Key findings from this body of work include: AOD-9604 stimulated proteoglycan synthesis in bovine cartilage explants in a dose-dependent manner The peptide promoted the differentiation of mesenchymal stem cells toward the chondrocyte lineage In a rabbit model of osteoarthritis, intra-articular injection of AOD-9604 was associated with improved cartilage scores and reduced degradation markers compared to controls The effects were observed without the IGF-1 elevation or metabolic side effects associated with full-length growth hormone Clinical Observations Physicians prescribing AOD-9604 in clinical peptide therapy settings have reported improvements in joint comfort and function among their patients

These findings are consistent with studies conducted in populations from the United States (181, 182)

(2021) "MOTS-c improves physical capacity in aged mice." Published in Nature Communications